Endocrine Abstracts

Modern lifestyle diminished significantly the need of everyday exercise, which is probably one of the major factors leading to the development of several metabolic diseases including type 2 diabetes, hypertension and atherosclerosis with its deadly consequences. Epidemiological studies proved that higher levels of cardio-respiratory fitness are associated with lower mortality irrespective of fat stores. Physical activity reduces all-cause, cardiovascular as well as cancer asso...

Objective: Saturated fatty acids (FAs), e.g. stearic acid (SA), induce apoptosis in pancreatic β-cells while unsaturated FAs, e.g. oleic acid (OA) have nearly no detrimental effect. Moreover, unsaturated FAs are capable of inhibiting the pro-apoptotic effect of saturated FAs. Hypoxia is also known to have deleterious effects on β-cell function and viability. In the present study, we have tested the modulatory effect of hypoxia on the effect of FAs on the growth and v...